Submit Your Full Proposal · Lotus Neuro 2026 POP Challenge

02 — DOCUMENTS

Upload your four proposal documents

Keep each tight — the review committee reads dozens of applications. The first three are required; the letter of support is optional if you are testing a homegrown molecule.

Study Proposal

6 pages maximum

The scientific and operational case for adding a FUS arm to your existing trial.

Upload study proposalPDF or DOCX · up to 10 MB

References

2 pages maximum

Citations supporting the rationale and methodology in Document #1.

Upload referencesPDF or DOCX · up to 10 MB

Budget

single PDF

Itemized cost breakdown for the FUS arm — device time, staff, imaging, monitoring, regulatory.

Upload budgetPDF · up to 10 MB

Letter of Support

single PDF · optional

From the biopharma collaborator providing the asset. Skip this if you are testing a homegrown molecule.

Upload letter of supportOptional · PDF · up to 10 MB

Document #1 · Study Proposal

Required information for the 6-page study proposal

Scientific rationale for asset + FUS combo

What is the scientific evidence to date that suggests FUS could enhance brain delivery of the specific asset?

Safety risk assessment of asset + FUS combo

What is the rationale to support the safety profile of asset dose + FUS?

Study plan

What are the study details incorporating a FUS arm into the ongoing trial?

Biomarker plan

How will TE, PK, and/or PD be detected and measured?

Patient recruitment

How many patients are required to sufficiently power the study? What are the plans and expectations for patient access and recruitment?

Overall logistics

What is the timeline and budget for the proposed study? What are the key logistical milestones leading up to first-patient enrollment?

Submitting sends your documents to the review committee. You'll receive an email confirmation, and notification of results by August 15, 2026.

Congratulations — you've been selected to submit a full proposal.

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